ARBs are specific angiotensin II
receptor antagonists with many properties similar to those of ACEIs.
Unlike ACEIs, persistent dry cough is not a problem. As with ACEIs,
they are contraindicated in pregnancy and bilateral renal artery
stenoses, and should be used with caution in patients with renal
There is no difference in antihypertensive effect among the currently available ARBs.
large outcome studies have demonstrated that ARBs are beneficial in the
treatment of early and advanced type 2 diabetic nephropathy. A recent
trial showed that an ARB, when compared to a beta-blocker, was able to
prevent more cardiovascular morbidity and death in hypertensive
patients with LVH6.
| ARBs||Starting Dose||Recommended Maximum Dose|
| Candesartan||8 mg||16 mg|
| Irbesartan||150 mg||300 mg|
| Losartan|| 50 mg|| 100 mg|
| Telmisartan|| 40 mg|| 80 mg|
| Valsartan||80 mg|| 160 mg|
Table 16: ARBs commonly used for the treatment of hypertension in Malaysia.
ReferenceClinical Practice Guidelines on the Management of Hypertension